The story of the relationship between Karamakate, an Amazonian shaman and last survivor of his people, and two scientists who work together over the course of forty years to search the Amazon for a sacred healing plant.

At an isolated frontier outpost, a colonial magistrate suffers a crisis of conscience when an army colonel arrives looking to interrogate the locals about an impending uprising, using cruel tactics that horrify the magistrate.

During the marijuana bonanza, a violent decade that saw the origins of drug trafficking in Colombia, Rapayet and his indigenous family get involved in a war to control the business that ends up destroying their lives and their cultur