Flint Lockwood now works at The Live Corp Company for his idol Chester V. But he's forced to leave his post when he learns that his most infamous machine is still operational, and is churning out menacing food-animal hybrids.

Convinced they'd be better off raising themselves, the Willoughby children hatch a sneaky plan to send their selfish parents on vacation. The siblings then embark on their own high-flying adventure to find the true meaning of family.