A young girl in Bogotá witnesses her parents' murder and grows up to be a stone-cold assassin.

In the not-too-distant future, as a final response to terrorism and crime, the U.S. government plans to broadcast a signal making it impossible for anyone to knowingly commit unlawful acts.

Frank Martin is forced to deliver Valentina, the kidnapped daughter of a Ukrainian government official, from Marseilles to Odessa on the Black Sea. En route, he has to contend with thugs who want to intercept Valentina's safe deliver

In Istanbul, retired CIA operative Bryan Mills and his wife are taken hostage by the father of a kidnapper Mills killed while rescuing his daughter.

Accused of a ruthless murder he never committed or witnessed, Bryan Mills goes on the run and brings out his particular set of skills to find the true killer and clear his name.