In 18th-century France, the Chevalier de Fronsac and his Native American friend Mani are sent to the Gevaudan province at the king's behest to investigate the killings of hundreds by a mysterious beast.

In 1714 Peru, a friar is tried by the Inquisition for questioning God's intentions when five die in the collapse of an Andean rope bridge.

A nurse, a policeman, a young married couple, a salesman and other survivors of a worldwide plague that is producing aggressive, flesh-eating zombies, take refuge in a mega Midwestern shopping mall.