What happens when revenge has mutated into a type of madness?

Gru, Lucy, Margo, Edith, and Agnes welcome a new member to the family, Gru Jr., who is intent on tormenting his dad. Gru faces a new nemesis in Maxime Le Mal and his girlfriend Valentina, and the family is forced to go on the run.

A world in which a compulsory operation wipes out physical differences and makes everyone pretty.