A twisted tale of two estranged sisters whose reunion is cut short by the rise of flesh-possessing demons, thrusting them into a primal battle for survival as they face the most nightmarish version of family imaginable.

Baltimore. New Year's Eve. A talented but troubled police officer (Shailene Woodley) is recruited by the FBI's chief investigator (Ben Mendelsohn) to help profile and track down a disturbed individual terrorizing the city.