A doctor devotes his life's work to finding a cure for breast cancer.

A hostile alien wreaks havoc on the cast and crew of an adult movie.

Two childhood friends from South Boston turn to crime as a way to get by, ultimately causing a strain in their personal lives and their friendship.

Over the course of one week in 1988, the search for a missing teammate, parental expectations, a burgeoning sexual awakening and the rock concert of the century all threaten to jolt a 16-year-old into adulthood.

A hard-core New York Giants fan struggles to deal with the consequences when he is beaten up by his favorite player.

A teenage boy with a sex therapist mother teams up with a high school classmate to set up an underground sex therapy clinic at school.

Two passengers and the conductor discover that a man has passed away on their night train cabin. They come across a mysterious object in a box the dead man was carrying and they all wish to keep for themselves.

A father in a south-Texas border town starts trafficking drugs to pay for his son's cancer treatment.

An American drug dealer living in Tokyo is betrayed by his best friend and killed in a drug deal. His soul, observing the repercussions of his death, seeks resurrection.

Flamboyant and gay Austrian Brüno looks for new fame in America.

Unable to cope with a recent personal tragedy, LA's top celebrity shrink turns into a pothead with no concern for his appearance and a creeping sense of his inability to help his patients.

Mr. Jack and Sweet Stephen cruise aimlessly through the streets of LA speculating about life, death, divine will and the force of power that predetermines their existence. Mr. Jack attempts to illustrate to his sidekick the delica...

A man and his friends come up with an intricate and original plan to destroy two big weapons manufacturers.

Milo has to get his brother to rehab before 8pm to keep him from doing 3 years in prison. Milo films the trip as documentary while his partner/Olivia Wilde drives, starting 5:20am in LA. Complications follow.

Spoof horror in which a group of college kids do a semester abroad in Romania and realise that if the partying doesn't kill them, the vampires just might!

The master comedian performs in Washington DC and gives his wry observations about life, politics and his health.

Eight housemates on a fake animated reality TV show realize they've been canceled and set off on a journey to get back on the air.

A look at life for a group of high school students as they grapple with issues of drugs, sex, and violence.

The story of Boy George, the famous androgynous lead singer of the band, Culture Club.

An unflinching Ozark Mountain girl hacks through dangerous social terrain as she hunts down her drug-dealing father while trying to keep her family intact.

A young drug dealer sells his soul to the devil in order to become the #1 seller on the block.

An ice cold tale of misguided ambition and savage revenge. Set in the bowels of an iconic derelict Los Angeles high-rise, we follow Lauren and her real-estate investing fiancé as they discover first hand what happens when a madman...

Eddie 'The Fat Man' Jackson and Courtney 'The Field Marshal' Brown were labeled 'Kingpins' in an era where their names reigned supreme in Detroit. Accumulating more than a million dollars a month in heroin sales, these childhood f...

A mysterious pill that enables the user to access 100% of his brain's abilities transforms a struggling writer into a financial wizard, but it also puts him in a new world with many dangers.

A lawyer defending a wealthy man begins to believe his client is guilty of more than just one crime.

When her wild younger sister Ashley, who suffers from bipolar disorder and drug addiction, goes missing, Libba Phillips pours all her time and energy into finding Ashley and bringing her home. As the years go by, Libba refuses to ...

The scientist Susan Carter is researching the rehabilitation of addicts using an experimental drug in her rehab center. After her death, her idle son Brian Carter is forced by his friend Simon to travel to the property that he had...

An amateur racer gets involved in illegal street racing after the death of his brother.

An unorthodox Irish policeman with a confrontational personality is partnered with an up-tight F.B.I. agent to investigate an international drug-smuggling ring.

A young girl in Bogotá witnesses her parents' murder and grows up to be a stone-cold assassin.

Paul, a closeted and self-unaware CEO in his 50's, retires and begins falling for a younger man half his age whom he meets in a dog park.

A kid from the Midwest moves out to Hollywood in order to follow in his parents footsteps, and become a porn star.