A 74-year-old lizard named Leo and his turtle friend decide to escape from the terrarium of a Florida school classroom where they have been living for decades.

Rango is an ordinary chameleon who accidentally winds up in the town of Dirt, a lawless outpost in the Wild West in desperate need of a new sheriff.

While attempting to find a research facility on an island, a group of activists discovers two giant creatures that have escaped the facility.