The story of the relationship between Karamakate, an Amazonian shaman and last survivor of his people, and two scientists who work together over the course of forty years to search the Amazon for a sacred healing plant.

Cristina, a journalist of Mexican origin, travels to her ancestral home in Veracruz to investigate a story of sorcery and healing. There, she is kidnapped by a group of locals who claim she's the devil incarnated.

After her young son is killed in a tragic accident, a woman learns of a ritual which will bring him back to say goodbye, but when she disobeys a sacred warning, she upsets the balance between life and death.