Rayne, the half-human/half-vampire warrior, ventures to America's 1880's Wild West to stop the vampired Billy the Kid and his posse of vampire cowboys.

Rayne joins a resistence group to fight against the Nazis during world war two.

In the eighteenth century, a vampire escapes from the freak show, in which she once participated, and teams up with a group of vampire slayers to kill the man who raped her mother.