When Manny finds a mysterious collar and puts it on his dog, Rufus, he magically turns into a human boy. Although he doesn't know how to act normal, he becomes the most popular kid in school.

Rufus is a dog but turns into a human with a pendant. He meets a girl named Kat who asks him to go out. Kat is a cat who can also turn into a human as well.

Scott and Emily are at his grandmother's home when they suddenly discover a mysterious creature. They have a mission: with the help of an ancient spell book, they'll gather some ingredients to make a magic dust to save their world.