Early 1970s. Four strangers check in at the El Royale Hotel. The hotel is deserted, staffed by a single desk clerk. Some of the new guests' reasons for being there are less than innocent and some are not who they appear to be.

Miami detectives Mike Lowrey and Marcus Burnett must face off against a mother-and-son pair of drug lords who wreak vengeful havoc on their city.

On Halloween night in New Salem, Radio DJs Chilly Billy (Corey Taylor) and Paul (Zach Galligan) tell a twisted anthology of terrifying local myths that lead to a grim end for small-town residents.