A shy student trying to reach his family in Ohio, a gun-toting bruiser in search of the last Twinkie and a pair of sisters striving to get to an amusement park join forces in a trek across a zombie-filled America.

Columbus, Tallahassee, Wichita, and Little Rock move to the American heartland as they face off against evolved zombies, fellow survivors, and the growing pains of the snarky makeshift family.