"Me Estas Matando Susana" takes us on Eligio's quest to find and recover his wife, Susana, who without a word, left Mexico City behind for a writer's conference held in the chilly U.S. heartland.

Follows the journey of John and Colt, gunfighters and sometimes lovers, on parallel but very different journeys through an underground dueling culture.

A woman brings her family back to her childhood home, which used to be an orphanage for handicapped children. Before long, her son starts to communicate with an invisible new friend.