James, a twenty-something New Yorker, struggles to take control of his self-destructive behavior in the face of momentous family challenges.

A student receives a serial killer's brain in a transplant after being thrown into a pool with no water in it.

A 6 y.o. Inuit boy runs off a snowy roof in Copenhagen and dies. Smilla, a half Inuit who lives in the building and knows the boy, looks into it. What makes an acrophobic boy run up on the roof? The clues take her to Greenland.