Dave is a married man with three kids and a loving wife, and Mitch is a single man who is at the prime of his sexual life. One fateful night while Mitch and Dave are peeing in a fountain, lightning strikes and they switch bodies.

This follow-up to the original movie "Natalee Holloway" closes in on the ongoing mystery of what exactly happened to the Alabama teenager who mysteriously disappeared during her senior class trip to Aruba.