When the strain of tragedy was too much for a young couple in Appalachia, prescription pills became the medicine to ease the pain.

John Beckwith and Jeremy Grey, a pair of committed womanizers who sneak into weddings to take advantage of the romantic tinge in the air, find themselves at odds with one another when John meets and falls for Claire Cleary.

In the future, an alien race uses androids as bombs to attack Earth. A government weapons specialist is accused of being one such android and sets out to prove his innocence.

A pregnant New York City social worker begins to develop romantic feelings for her gay best friend, and decides she'd rather raise her child with him, much to the dismay of her overbearing boyfriend.

Zane, an astronomer, discovers intelligent alien life. But the aliens are keeping a deadly secret, and will do anything to stop Zane from learning it.

A couple goes on a cross-country road trip from North Carolina to Los Angeles. Along the way they visit filming locations for some of their favorite movies while they fall in and out of love.