In an old school Las Vegas casino, its top gambling jinx breaks his curse when he falls in love, much to his boss' consternation.

Ten years after he was pushed down a well, a young man kills off the neighborhood bullies who tormented him and leaves their body parts as presents for the one girl who was kind to him.

When contact with the spaceship USG Ishimura is lost after a Necromorph outbreak, Earth sends the ship USG O'Bannon to investigate, but contact is lost with them as well.

Dante journeys through the nine circles of Hell -- limbo, lust, gluttony, greed, anger, heresy, violence, fraud and treachery -- in search of his true love, Beatrice.