A madman who believes he's a doctor comes to the town where his crazy father was killed, and soon begins murdering people and becoming infatuated with a teenage girl who has a heart condition.

Alexandra "Alex" Mack develops powerful abilities after a chemical factory accident. She struggles to balance her ordinary life with extraordinary misadventures as a result.

Activists arrive in Seattle, Washington en masse to protest a meeting of the World Trade Organization. Riots and chaos ensue as demonstrators successfully stop the WTO meetings.