The unlikely friendship that kindles between a struggling stand-up comedian from L.A., forced to move back home with his tail between his legs, and a tragically flawed, but charming and charismatic, alcoholic dermatologist.

Folk rock and bluegrass musicians Mumford & Sons, Old Crow Medicine Show and Edward Sharpe and the Magnetic Zeroes travel together by train from San Francisco to New Orleans in the spring of 2011.