Set in Japan, Isle of Dogs follows a boy's odyssey in search of his lost dog.

During her family's move to the suburbs, a sullen 10-year-old girl wanders into a world ruled by gods, witches, and spirits, and where humans are changed into beasts.

An American businessman visiting Nagoya, Japan, meets a woman in a hotel bar. Returning to her room, 3 ninjas kill her and wound him, but he sees the ninja boss' face. Now, he's the prime target of a dangerous ninja cult.