City of Vultures 2 picks up as a brash of murders engulfs the Chicago streets. Richard Steele (Marcus Carothers), commonly known as "G", positions himself as the centerpiece of criminal activity on the city's Southside.

Johnny is a successful bank executive who lives quietly in a San Francisco townhouse with his fiancée, Lisa. One day, putting aside any scruple, she seduces Johnny's best friend, Mark. From there, nothing will be the same again.