While caring for his ailing wife, an American engineer in Pakistan stumbles upon a deadly pharmaceutical conspiracy.

Following the events of Tiger Zinda Hai, War, and Pathaan, Avinash Singh Rathore returns as Tiger but this time the battle is within. He has to choose between his country or family as an old enemy is after his life, who claims that his family was killed by Tiger. He holds Tiger captive in Pakistan as the Indian agent's loyalty towards his country faces its biggest test.