In a mythical land, a man and a young boy investigate a series of unusual occurrences.

On a journey to find the cure for a Tatarigami's curse, Ashitaka finds himself in the middle of a war between the forest gods and Tatara, a mining colony. In this quest he also meets San, the Mononoke Hime.

Beautiful Yuko arrives home from the US to stay with her brother, Takuya at his posh mansion in the countryside. Soon Yuko witnesses many strange and perverse events in the house.