Picking up directly from the previous movie, vampire warrior Selene and the half werewolf Michael hunt for clues to reveal the history of their races and the war between them.

An American diplomat and his fiancée venture into the sordid underworld of sex and pornography in Budapest, Hungary to find out who is blackmailing them with a porno video taken of them with a prostitute.

Selene, a vampire warrior, is entrenched in a conflict between vampires and werewolves, while falling in love with Michael, a human who is sought by werewolves for unknown reasons.