Folk rock and bluegrass musicians Mumford & Sons, Old Crow Medicine Show and Edward Sharpe and the Magnetic Zeroes travel together by train from San Francisco to New Orleans in the spring of 2011.

Elise and Didier fall in love at first sight, in spite of their differences. He talks, she listens. He's a romantic atheist, she's a religious realist. When their daughter becomes seriously ill, their love is put on trial.