At a secret government facility, behavioral scientist Rachel Moreno runs an experimental drug trial on a group of prison inmates to find out what caused their violent behavior.

After he receives a new cancer diagnosis and she is fired from her job as a sex columnist, Bailey and Darla take a road trip that forces them to get intimate with their issues, as well as each other.

In 1972, the patients and doctors at Stephens Sanitarium were brutally murdered. Over forty years later, the only known survivor returns only to find the ghosts of the past have not been resting in peace.