At a secret government facility, behavioral scientist Rachel Moreno runs an experimental drug trial on a group of prison inmates to find out what caused their violent behavior.

After unexpectedly, and mysteriously, inheriting his estranged grandmother's mansion, Stanley DeFeo finds himself in the small town of Amityville - surrounded by buried family secrets and a sinister plot against him.

It follows Reno, a newly married gunfighter seeking a quiet life with his bride. When Reno kills a bandit in self-defense, he finds them both pulled back into his old ways. Clarence Bishop, the corrupt mayor of their locale will n...